Authorities in Cornwall, England, along with the Public Works Department, have been searching for an enigmatic driver who allegedly took matters into their own hands and filled in a massive pothole in the center of the road with cement.
Although residents of Cornwall had to endure extra difficulties to avoid the region at the top of Tanhouse Road and Bodmin Hill in Lostwithiel due to the enormous hole that was in the midst of the tarmac, British people are well aware that the roads aren’t always the greatest.
The road was declared formally closed at the start of April. A representative for the Cornwall Council stated that the road’s surface degradation was caused by an ongoing dispute with drainage.
However, following a month of total government inaction, an unnamed person became quite agitated over the enormous pothole and made the decision to personally fill it with concrete over the first weekend of May. For a little while, the do-it-yourself fix succeeded, and the road was briefly reopened. However, Cormac, the road repair business employed by Cornwall Council, once again stopped the road since their crew hadn’t completed the work in a formal manner.
The Cornwall Highways chiefs are currently searching for the individual who is in charge of this. They added that the signs had been taken down without permission by an unidentified person who had completed the work.
The firm stated that until it catches up with the backlog of pothole repairs, the route would be closed until June 9th. “If information regarding who carried out the works becomes known in the community, I would be grateful if details could be shared,” stated a manager at Cornwall Highways. Colin Martin, the Cornwall councilor for Lanreath and Lostwithiel, said that this pothole served as the “ideal illustration of how the public sector as a whole is collapsing as a result of underfunding.”
“The road has been closed again and will remain closed until it is ‘properly’ repaired by Cormac,’ but they say this could be weeks away as all available teams have been diverted to filling smaller potholes on roads which are still open,” Mr. Martin said in an interview with Cornwall Live. The cash allocated for preventative maintenance and road resurfacing has been reduced by the Conservative-run Cornwall Council throughout the last two years. This imprudent choice has led to potholes popping up all throughout Cornwall more quickly than Cormac can patch them.
This is not the first time a citizen has taken up the role of the local government. A Toronto citizen noticed in 2017 that the community garden would benefit greatly from a new set of park stairs. However, the city estimated that it would cost between $65,000 and $150,000. Thus, for a meager $550, the man built it himself. Continue reading to learn what they did since, of course, the city was not at all pleased.
We’ve All Waited for It: Scientists Created a Drug That Can Help Regrow Lost Teeth
The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
Leave a Reply