The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
My Dad Kicked Me out Because He and My Stepmom Had a Baby — Karma Quickly Taught Him a Lesson
When Carla’s father demanded she move out to make room for a new baby, she felt her world crumble again. With the help of her determined grandparents, she found the strength to rebuild her life and uncover the family secrets that forced her to choose between independence and familial ties.
My name is Carla, and I’m 21 years old. My life hasn’t been easy, especially after losing my mom when I was 10. She was my rock, and when she passed, my world turned upside down.
Young woman | Source: Pexels
Dad remarried when I was 15. His new wife, Linda, came with a daughter, Megan, who was 16 then. Later, Dad and Linda had a son, Jimmy, and just recently, they had a baby girl.
I remember the day Dad told me they were getting married. “Carla, I think it’s time I move on,” he said, looking uncomfortable. “Linda is good for us.”
“Us?” I asked, not sure how I felt about it.
An unsure woman | Source: Midjourney
“Yes, us. She has a daughter your age. It might be nice for you to have someone around.”
Linda moved in, and things were… different. Linda was kind but distant at first, but we managed. Megan and I grew very close over time. We became like sisters, sharing everything and helping each other through tough times.
When Jimmy was born, Linda became a stay-at-home mom. That’s when things really changed.
Woman with her baby | Source: Pexels
I started working when I turned 16. I wanted my own money, so I didn’t have to rely on Dad. I worked at the local grocery store, and it felt good to be independent. I saved up for my own clothes, school supplies, and little things I wanted.
One day, when I was 18, Dad called me into his “office.” “Carla, you’re an adult now,” he said, avoiding eye contact. “You need to start paying rent. It’s only $500, just a symbolic amount.”
A man reading a newspaper | Source: Midjourney
I was shocked. “But, Dad, why? I’ve been saving for college.”
“It’s time to contribute,” he insisted. “You’ll still get food and other essentials.”
We argued, but in the end, I agreed. It was tough, but I managed.
Five months ago, everything changed again. Dad came to my room with Linda. “Carla, we need to talk,” he said, his voice firm. “Linda’s pregnant, and we need your room for the baby. You have two months to move out.”
Dad tells Carla to move out | Source: Midjourney
I stared at him in disbelief. “What? You have two offices! Why can’t you use one of those?”
Linda looked apologetic but said nothing. Dad just repeated, “You need to move out.”
I felt like my world was falling apart again. I didn’t know what to do. I called my Aunt Lisa in tears. “Aunt Lisa, Dad is kicking me out. Can I stay with you?”
Aunt Lisa was furious. “Of course, you can stay with me. No rent needed. I’ll handle your father.”
Furious woman | Source: Pexels
The next day, Grandpa showed up at our house. He talked to Dad for a long time. I heard raised voices, but I couldn’t make out the words. Afterward, Grandpa came to me. “Carla, you have three choices,” he said gently. “You can stay here, move in with me and Grandma, or find your own place, and I’ll cover the rent.”
I was relieved but conflicted. I decided to stay for a bit longer, but things got worse. Dad and Linda became cold and distant. Even Megan noticed. “Why are they so mad at you?” she asked one night.
Sad teenage girl | Source: Pexels
“I don’t know,” I sighed. “I just don’t know.”
Eventually, I told Grandpa I wanted to move out. I packed my things and moved into Grandpa’s rental unit. It was a cozy apartment, and Grandpa had thought of everything. There was a fridge, a stove, and all the essentials I needed. He even gave me a check for $15,000.
Small apartment | Source: Pexels
“This is to help you start on your own,” Grandpa said with a smile. “As long as you’re working or studying, you can live here rent-free.”
“Thank you, Grandpa,” I said, hugging him tightly. “I don’t know what I would do without you.”
The first few weeks were a mix of emotions. I missed my family, especially Megan and Jimmy. But at the same time, I loved the feeling of independence. It was nice to have my own space and make my own decisions.
Young woman relaxes at home | Source: Pexels
I had low contact with Dad and Linda. They didn’t call, and I didn’t visit.
One day, I decided to visit Aunt Lisa. I needed to talk to someone about my feelings. When I arrived, she welcomed me with open arms.
“Carla, it’s so good to see you,” she said, pulling me into a hug. “How have you been?”
“I’ve been okay,” I replied. “It’s just… I miss them, you know?”
“I know, sweetheart,” she said softly. “But you have to do what’s best for you.”
Confident woman | Source: Pexels
As we talked, my cousin overheard us and laughed. “I bet Dad misses you because Grandpa is making him pay for kicking you out,” he said.
“What do you mean?” I asked, confused.
“Grandpa owns the house, not Dad,” my cousin explained. “Grandpa is charging him rent and making him repay the $15,000 he gave you.”
Young man talks to a woman | Source: Pexels
I was stunned. “I had no idea,” I said, shaking my head. “I didn’t realize how much Grandpa had been supporting us.”
“Grandpa’s been helping a lot,” Aunt Lisa added. “He’s been subsidizing your Dad for years. And now, he’s making sure you’re taken care of too.”
It felt like everything clicked into place. Dad was struggling not because he missed me, but because Grandpa was making him pay for his actions. I felt a mix of anger and sadness. How could Dad do this to me?
Shocked young woman | Source: Pexels
I decided to visit Grandpa and Grandma. I needed to hear their side of the story. When I arrived, they welcomed me warmly.
“Carla, we’ve missed you,” Grandma said, hugging me tightly. “How’s the apartment?”
“It’s great, Grandma. Thank you so much,” I said. “But I need to know more about what’s going on with Dad.”
Woman and her grandmother | Source: Pexels
Grandpa sighed. “Your father has been relying on us financially for years,” he explained. “We’ve been helping with school, healthcare, and other expenses. When he kicked you out, it was the last straw.”
“I didn’t know,” I said quietly. “Why didn’t anyone tell me?”
“We didn’t want to burden you,” Grandpa said. “But you deserve to know the truth. Your father needs to learn responsibility, and this is the only way we can teach him.”
thoughtful elderly woman | Source: Pexels
“But what about Megan and Jimmy?” I asked. “And the new baby?”
“They’ll be fine,” Grandpa reassured me. “We’re still helping them. We set up funds for all of you, including Megan. We want everyone to have the same opportunities.”
I felt a wave of relief and gratitude. “Thank you, Grandpa,” I said. “I’m so lucky to have you.”
As I drove back to my apartment, I thought about everything I had learned. My heart ached for my siblings, but I knew I couldn’t go back. I needed to stay independent.
Young woman driving | Source: Pexels
I decided I needed to maintain a relationship with my siblings, even if things were tense with Dad and Linda. Megan and I talked regularly. She would text me about her day, school, and everything in between.
A few days later, Dad called again. “Carla, let’s have dinner,” he suggested. “We need to talk.”
I agreed, hoping we could clear the air. We met at a quiet restaurant, and the tension was palpable.
Young woman in a cafe | Source: Pexels
“Carla, I’m sorry for everything,” Dad started. “I miss you. We all miss you.”
“Dad, I miss you too,” I replied, trying to keep my emotions in check. “But I can’t just come back like nothing happened.”
“I understand,” he said, looking down. “I didn’t realize how much I was relying on Grandpa. I’ve been trying to sort things out.”
Dad in the restaurant with Carla | Source: Pexels
“I appreciate that,” I said. “But I need you to respect my space. I’ll visit and stay in touch, but I can’t move back. It’s better for me this way.”
“Okay,” he said, nodding slowly. “We’ll make it work. Just don’t stay away too long.”
“I won’t,” I promised.
Dinner was a step in the right direction, but it was clear things wouldn’t be the same. I was determined to set boundaries and stick to them.
Happy middle-aged man | Source: Pexels
Reflecting on everything, I felt a deep gratitude for my grandparents. Without them, I would have been lost. Grandpa’s tough love with Dad was necessary, and I respected him even more for it. Grandma’s gentle support had been a constant comfort.
One evening, I sat with Grandpa and Grandma, talking about the future. “I want to finish college and start my career,” I said. “You both have done so much for me. I want to make you proud.”
“You already make us proud,” Grandpa said, his eyes twinkling. “Just keep working hard, and you’ll do great things.”
Happy elderly man | Source: Pexels
“Remember, we’re always here for you,” Grandma added. “No matter what.”
I hugged them both, feeling incredibly lucky. Their support had given me the strength to move forward.
Carol hugs her grandfather | Source: Midjourney
As I settled into my apartment that night, I felt a renewed sense of purpose. My family’s dynamics were complicated, but I was determined to navigate them with grace. I would maintain my relationships with Megan and Jimmy, set boundaries with Dad, and focus on building a bright future.
With the love and support of my grandparents, I knew I could achieve anything.
If you liked this story, consider checking out this one! When Sarah’s estranged father appeared at her graduation, claiming her grandparents had hidden her from him, her world turned upside down. As shocking truths unfolded, Sarah faced the painful task of discerning love from lies, unraveling a web of deceit that threatened to destroy her family bonds.
This work is inspired by real events and people, but it has been fictionalized for creative purposes. Names, characters, and details have been changed to protect privacy and enhance the narrative. Any resemblance to actual persons, living or dead, or actual events is purely coincidental and not intended by the author.
The author and publisher make no claims to the accuracy of events or the portrayal of characters and are not liable for any misinterpretation. This story is provided “as is,” and any opinions expressed are those of the characters and do not reflect the views of the author or publisher.
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