The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
I Was Adopted 25 Years Ago – Last Month My Bio Father Knocked on My Door Demanding 50% of Everything I Own
The man at my door looked like trouble—a stranger with hard eyes and a crooked smile. But when he opened his mouth, he didn’t ask for directions or offer a sales pitch. His words made my blood run cold and the demand he made next changed everything.
I had just put our four-year-old down for his afternoon nap when the doorbell rang. Not a polite ding-dong—this was an aggressive, finger-jamming assault on the button. The kind of ring that made you think someone was delivering terrible news.
Senior man knocking on the front door of a house | Source: Pexels
I grabbed a dish towel from the counter, wiping my hands as I headed for the door. A thought crossed my mind: maybe it was the delivery guy, frantic over a missing package. But when I swung the door open, I was greeted by someone far more unsettling.
The man standing there looked rough like he’d spent decades punching through life with bare fists and losing more often than not. Late 50s, maybe, with a slumped posture and a face that hadn’t seen sunscreen in decades.
Closeup of a senior man | Source: Midjourney
His eyes flitted around the hallway, lingering on the marble floors, the chandelier, the subtle touches of a comfortable life. Then his gaze snapped back to me, a crooked smile spreading across his weathered face.
“Emily,” he said, his voice a strange mix of gravel and nerve. “It’s me. Your father.”
I blinked. For a second, I thought I’d misheard him. “I’m sorry, what?”
He shifted his weight, clearly enjoying my confusion. “Your father,” he repeated, louder this time, as though that would make it sink in. “You don’t recognize me?”
“No,” I said flatly, gripping the edge of the door. “I don’t.”
Senior woman standing in a room with crossed arms | Source: Midjourney
And I didn’t. I had no memories of this man, and yet his presence felt like a hand yanking open a closet I’d sealed shut years ago. My biological father was a shadow, a piece of my past I’d worked hard to forget. And now, here he was, standing on my porch, smug and uninvited.
“That’s fine,” he said, shrugging. “I’m not here for pleasantries. I’m here to claim what’s mine.”
My stomach dropped. “What are you talking about?”
“Half,” he said. “Of everything. Half of your life.“
Senior man talking to his estranged daughter | Source: Midjourney
His smirk widened.”I heard you’re doing well for yourself. Very well. Nice house, nice car. Married with a kid.” His eyes darted to the sparkling wedding band on my finger. “I figured it’s time you shared the wealth—with the man who made it all possible.”
I blinked, stunned. “Excuse me?”
“Oh, don’t play dumb,” he said, leaning against the doorframe like he had every right to be there. “Without me, you wouldn’t be here. You wouldn’t have been adopted by that rich family of yours. I gave you that chance by letting you go. And now it’s time you paid me back. I want fifty percent of everything you own.” His hand swept dramatically over the entryway. “I like this mansion you’re living in.”
Hallway of a beautiful mansion | Source: Pexels
The audacity of his words hit me like a slap. My heart pounded as memories I had buried long ago began to claw their way back. Nights in the orphanage under a thin, scratchy blanket, the dimly lit halls that always smelled like overcooked cabbage. And the desperate hope that every visitor might be someone coming to take me home.
I folded my arms, trying to steady myself. “You gave me up. Do you know what that was like for me? Do you have any idea—”
He cut me off, waving a hand dismissively. “Spare me the sob story. You’re doing great now, aren’t you? That’s what matters. And you’re welcome, by the way.”
Senior man talking to his estranged daughter | Source: Midjourney
“You’re insane,” I shot back, my voice shaking. “You don’t get to waltz into my life after twenty-five years and demand anything.”
Before he could respond, his expression changed. The smirk faltered, and his eyes widened. Confusion—or was it fear?—flashed across his face as he looked past me, his focus snapping to something behind my shoulder.
“What the hell is that?” he muttered, his voice low but urgent.
I turned to see what had caught his attention.
Curious woman turning around | Source: Midjourney
There, stepping into the foyer with the calm confidence of someone who wouldn’t tolerate nonsense, was my husband, Daniel. In one hand, he held a tablet, in the other, our toddler’s well-loved stuffed bear. His sharp blue eyes took in the scene with a single sweep, lingering briefly on me before locking onto the man at the door.
The sight of Daniel seemed to deflate the boldness radiating from my biological father. His smirk faded, replaced by a flicker of uncertainty.
“Who’s this?” Daniel asked his tone even but protective.
Serious man standing in a luxurious living room with crossed arms | Source: Midjourney
“My biological father,” I said, the words tasting bitter in my mouth. “Apparently, he thinks I owe him half of everything I own because he ‘let me go.’”
Daniel’s brows furrowed, his jaw tightening as he set the tablet and the stuffed bear on the console table. Then, he stepped forward, his broad frame filling the doorway like a shield. The air between the two men was electric, the tension palpable.
“You’ve got a lot of nerve showing up here,” Daniel said, his voice low and cutting. “Especially with that kind of demand.”
Serious young man standing in a luxurious living room with crossed arms | Source: Midjourney
My father puffed up slightly, though his posture betrayed his discomfort. “It’s not unreasonable,” he said, attempting to reclaim his swagger. “Without me, she wouldn’t have had the chance—”
“Chance?” Daniel cut him off sharply, taking another step forward. “Without you, she wouldn’t have suffered the way she did. She wasn’t adopted by a ‘rich family.’ She was dumped into foster care and passed from one awful home to another. One family treated her like a servant—had her scrubbing floors when she was barely tall enough to hold a mop. She ran away at sixteen with nothing but the clothes on her back. That’s the legacy you left her.”
Man confronting a senior man | Source: Midjourney
The man’s face turned an ugly shade of red, his mouth opening and closing as if he were searching for words but finding none.
The man blinked, his boldness faltering. “That’s not—”
“And she didn’t rebuild her life alone,” Daniel cut in, his voice steady but laced with righteous anger.
“We met in that same orphanage after my parents dumped me there. We were just kids, but we made a promise—to survive, to create the lives we deserved, and to find each other again someday. And we did. Every dollar we have, every brick in this house, every ounce of joy—we earned it. You didn’t give her anything but scars.”
Embarrassed senior man confronted by a young man. | Source: Midjourney
I felt tears well up, my chest tightening as Daniel’s words hit me like waves of both affirmation and emotion. He wasn’t just standing up for me; he was laying bare the battles we’d fought and won together.
The man’s face twisted, his emotions flickering between anger, humiliation, and something almost pitiable. “So you’re telling me,” he spat, “that she owes me nothing? After everything?”
Daniel stepped closer, his voice dropping to a low, dangerous tone. “Not a damn thing. Not your validation. Not your approval. And definitely not your greed. You don’t get to walk in here and rewrite history. She’s better off without you. Now get off my property before I call the police.”
Young man confronting a senior man | Source: Midjourney
For a tense moment, the man stood there, his jaw working like he was chewing on his pride. Then, shoulders slumping, he muttered something and turned away, walking down the driveway with heavy, defeated steps.
Daniel waited until the man disappeared down the street before closing the door. The silence that followed was deafening. He turned to me, and the sight of his steady gaze broke me into tears as he crossed the room, pulling me into his arms.
Couple hugging | Source: Midjourney
“You’re the strongest person I know,” he murmured, his voice soft now. “He doesn’t deserve a second of your energy. You built this life. We built this life.”
I nodded against his chest, the weight of the encounter slowly melting away. “You’re right,” I whispered. “I owe him nothing.”
Daniel pulled back just enough to meet my eyes, a small, determined smile on his face. “That’s because everything you are, you’ve earned. And no one—especially him—gets to take that from you.”
Couple hugging | Source: Midjourney
If this story kept you on the edge of your seat, you won’t want to miss another jaw-dropping tale: I found out that I was adopted but was shocked to discover the identity of my biological dad. It’s a heart-pounding journey full of surprises that you won’t see coming.
This work is inspired by real events and people, but it has been fictionalized for creative purposes. Names, characters, and details have been changed to protect privacy and enhance the narrative. Any resemblance to actual persons, living or dead, or actual events is purely coincidental and not intended by the author.
The author and publisher make no claims to the accuracy of events or the portrayal of characters and are not liable for any misinterpretation. This story is provided as “is,” and any opinions expressed are those of the characters and do not reflect the views of the author or publisher.
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