The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
Meghan Markle, 42, Sees Herself as Princess Diana’s ‘Heir’: Royal Expert Explains the Sign
In the realms of royalty and celebrity, few figures have captivated the public imagination as deeply as Princess Diana and Meghan Markle. Now, a royal expert has weighed in on Markle’s mindset.
Since the beginning of her relationship with Prince Harry, Meghan Markle has been heavily scrutinized by the public. Some have compared her to Princess Diana and others have said she could never measure up to her late-mother-in-law.
Princess Diana, a beacon of compassion and a disruptor of the traditional royal protocol, left a legacy of humanitarian work and personal vulnerability that reshaped the British monarchy.
Markle, an American actress turned Duchess of Sussex, has carved her own path, challenging norms and facing intense scrutiny while navigating her role within the same institution.
Recently, Markle, at the age of 42, embarked on a new venture, launching her lifestyle brand, American Riviera Orchard. This move, rich in ambition and personal expression, has reignited conversations about her connection to Diana’s legacy, stirring insights from royal experts and evoking varied reactions from the public.
American Riviera Orchard represents Markle’s latest step in crafting a life that merges public influence with private entrepreneurial ambition.
The brand, which will offer an array of homewares products, signifies her commitment to creating a legacy that transcends her royal title.
Notably, the brand’s launch coincided with The Diana Award ceremony, a decision that royal expert Tom Quinn suggests is no mere coincidence.
According to Quinn, Markle sees herself as “Diana’s heir,” a woman who, like her late mother-in-law, faces the media’s glare but strives to leverage her platform for personal and broader societal gain.
However, this alignment with Diana’s legacy has sparked debate, with some viewing it as a respectful nod to the past, while others criticize it as capitalizing on royal connections.
The parallels drawn between Markle and Princess Diana are not new. Prince Harry himself has often highlighted the similarities between the two most influential women in his life.
In their Netflix documentary series, “Harry & Meghan,” Harry emphasized Markle’s compassion, empathy, and warmth, traits he deeply associates with his mother.
This comparison extends beyond personality traits, touching on their shared experiences with media scrutiny and their desire to use their public platforms for advocacy and change.
In an excerpt from the documentary, Prince Harry recalled a night when he and Meghan were staying in a room at Buckingham Palace following a royal engagement.
Although most royal family members were there, including his grandmother, Queen Elizabeth II, the person the media chose to portray on the front page was Markle.
Many royal fans accused Markle of trying to steal the spotlight from other royals, but Prince Harry clarified that the media chose who they put on the front page, not the royals.
Yet, this connection to Diana’s legacy is a double-edged sword, offering both a source of inspiration and a potential point of contention within and outside the royal family.
Critics argue that Markle’s business endeavors, particularly the timing of her brand’s launch, reflect a calculated move to align her image with Diana’s enduring influence.
This perspective suggests a complex navigation of personal ambition and public perception, where every decision is scrutinized for its authenticity and respect for royal traditions.
Yet, supporters see Markle’s actions as a continuation of Diana’s legacy, a way of honoring her memory by embodying the same spirit of independence and social consciousness.
The launch of American Riviera Orchard, therefore, is more than just the introduction of a new brand. It’s a statement of identity and purpose from Markle, a declaration of how she wishes to be seen and remembered.
By aligning her entrepreneurial ventures with Diana’s legacy, Markle is carving a space where her work can be both personally fulfilling and beneficial to others.
However, the path she navigates is fraught with comparisons and expectations, where her every move is seen through the lens of her late mother-in-law’s shadow.
As Markle continues to build her brand and define her public persona, the conversation around her connection to Princess Diana’s legacy is unlikely to wane.
The move to start a business comes at the same time as Markle carving out her identity on hers and her husband’s new website. We previously reported that the pair launched a new website in which Markle altered her publicly-used name.
As Prince Harry and Markle launched the new website, they transitioned from the Sussex Royal URL handle to simply Sussex. Despite stepping back from official royal duties, they continue to use their titles. The website includes a section designed to offer the public more insight into their lives and work.
Notably, Meghan’s page introduces her using only her first name, omitting her family name. This decision reflects a common practice among British Royals, who are frequently referred to by their first names and titles.
Meghan’s narrative on the site includes her upbringing, painting a picture of her journey from a young South California girl to the influential figure she is today. The page also featured her advocacies for women, mental health, gender equality, and family care.
Meghan’s impact and recognition are also highlighted through her inclusion in various world rankings, marking her as a notable figure on the global stage.
Now residing in California as a mother of two, Meghan and Harry have embarked on a new chapter away from their roles as senior members of the British Royal Family.
Their children, Prince Archie and Princess Lilibet, whose names are emblematic of their continued connection to Harry’s heritage, are a significant part of their lives in America.
Following their move, the couple launched the Archewell Foundation and introduced the podcast “Archetypes,” initiatives that underline their ongoing commitment to public service and discourse.
Meghan’s details are available on the Royal Family’s official website, though it offers limited information about her advocacies and activities.
It mentions that she and her husband have stepped back as senior members, stating, “The Duchess will continue to support various charitable causes and organizations that align with her longstanding interests, including the arts, education access, women’s support, and animal welfare.”
Recently, in light of King Charles’ recent cancer diagnosis, Prince Harry returned to London to be by his father’s side. However, Meghan Markle decided to stay in America during this period.
The reasons behind Meghan’s choice to remain in America, while not confirmed were revealed by the King’s former butler, Grant Harrold.
“Meghan made the decision that it was best to stay home with the children, and maybe she feels that this is something Harry has got to do alone,” he said. “It’s his father. She’s aware of the close relationship and probably encouraged him to come over.
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